Forbes J Med. 2020; 1(3): 90-95 | DOI: 10.5222/forbes.2020.43153

Tissue Expression of ETS-Related Gene in Gastric Carcinomas

Sevil Sayhan¹, Gulden Diniz², Ismail Eren Birol³, Dudu Solakoglu Kahraman¹, Bulent Calik^4
1Izmir Tepecik Training and Research Hospital, Pathology Laboratory
²Izmir Democracy University, Pathology Department
³Karaman State Hospital, Pathology Laboratory, Karaman/ Turkey
⁴Izmir Tepecik Training and Research Hospital, Surgery Clinics

INTRODUCTION: The ETS-related gene (ERG) encodes a member of the erythroblast transformation-specific (ETS) transcription factor family that has been implicated in both tumor invasion and neovascularization. In this retrospective study, we have aimed to investigate the clinical significance of ERG tissue expressions in gastric cancer.
METHODS: We examined the expression of ERG protein by immunohistochemical staining in tissue specimens harvested from 172 primary gastric cancer cases.
RESULTS: ERG was expressed in normal vascular endothelium. ERG staining was defined as positive in 9.9 % (17 /172) of gastric cancer cases. According to clinicopathological characteristics, statistically significant differences were not observed between ERG expression and tumor invasion, lymph node and distant metastases, increased tumor stage, histological lymphatic and neural invasion. There were no significant differences in age, gender, or histopathological grading as for ERG expression.
DISCUSSION AND CONCLUSION: ERT expression in gastric cancers is not correlated with histological prognostic indicators.

Keywords: Gastric Carcinomas, ETS, ERG, prognostic criteria.

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Mide Karsinomlarýnda ETS ile Ýliþkili Genin Doku Ekspresyonu

Sevil Sayhan¹, Gulden Diniz², Ismail Eren Birol³, Dudu Solakoglu Kahraman¹, Bulent Calik^4
1Ýzmir Tepecik Eðitim ve Araþtýrma Hastanesi, Patoloji Laboratuvarý
²Ýzmir Demokrasi Üniversitesi, Patoloji Anabilim Dalý
³Karaman Devlet Hastanesi Patoloji Laboratuvarý
⁴Ýzmir Tepecik Eðitim ve Araþtýrma Hastanesi, Cerrahi Kliniði

GÝRÝÞ ve AMAÇ: ETS ile iliþkili gen (ERG), hem tümör invazyonunda hem de neovaskülarizasyonda rol oynayan eritroblast transformasyona spesifik (ETS) transkripsiyon faktör ailesinin bir üyesini kodlar. Bu retrospektif çalýþmada, mide kanserinde ERG doku ekspresyonlarýnýn klinik önemini araþtýrmayý amaçladýk.
YÖNTEM ve GEREÇLER: 172 primer mide kanserinden elde edilen dokularda ERG proteininin immünohistokimyasal boyama ile ekspresyonunu inceledik.

BULGULAR: ERG, normal vasküler endotelyumda eksprese edildi. Mide kanseri vakalarýnýn % 9,9'unda (17/172) ERG boyamasý pozitif olarak tanýmlandý. Klinikopatolojik özellikler açýsýndan, ERG ekspresyonu ile tümör invazyonu, lenf nodu metastazý, uzak organ metastazý, artan tümör evresi, lenfatik ve nöral invazyon arasýnda istatistiksel anlamlý iliþki gözlenmedi. Yaþ, cinsiyet veya histopatolojik derecelendirmede de ERG ekspresyonu açýsýndan önemli bir farklýlýk yoktu.
TARTIÞMA ve SONUÇ: Mide kanserlerinde ERT ekspresyonu histolojik prognostik göstergelerle iliþkili deðildir.

Anahtar Kelimeler: Mide Karsinomlarý, ETS, ERG, prognostik kriterler

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