�lac�n Do�adan Eczaneye Gizemli Yolculu�u

D�N�Z, G�lden; VEYSANO�LU, �ervan; �NAL, Simge; ARA�, Buket; D�zenli, Neslihan; KARAKAYALI, Emine M�ge

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�lac�n Do�adan Eczaneye Gizemli Yolculu�u [Forbes J Med]

Forbes J Med. 2024; 5(1): 1-8 | DOI: 10.4274/forbes.galenos.2023.44265

�lac�n Do�adan Eczaneye Gizemli Yolculu�u

G�lden D�N�Z¹, �ervan VEYSANO�LU², Simge �NAL², Buket ARA�², Neslihan D�zenli³, Emine M�ge KARAKAYALI²
¹�zmir Demokrasi �niversitesi, Buca Seyfi Demirsoy E�itim ve Ara�t�rma Hastanesi, Patoloji Klini�i, �zmir, Türkiye
²�zmir Demokrasi �niversitesi, Sa�l�k Bilimleri Enstitüsü, T�bbi Mikrobiyoloji Anabilim Dal�, �zmir, Türkiye
³�zmir Demokrasi �niversitesi T�p Fakültesi, T�bbi Farmakoloji Anabilim Dal�, �zmir, Türkiye

�nsanlar binlerce y�ld�r do�ada bulunan �e�itli maddeleri semptomlar�n giderilmesi, hatta hastal�klar�n iyile�tirilmesi amac�yla kullanm��lard�r. �la�lar bitki, hayvan, mikroorganizma gibi do�ada var olan kaynaklardan elde edilen ya da bu do�al maddeler �rnek al�narak laboratuvarda sentezlenen t�bbi ürünlerdir. Günümüzde baz� modern t�p uygulamalar�nda bile do�al bile�enlerden elde edilen ila�lar hala kullan�lmaktad�r. Ba�ta bitkiler olmak üzere bir�ok do�al ürün, �nemli farmakolojik etkilere sahip kimyasal bile�ikler i�erir ve bu bile�ikler, modern ila�larda kullan�lan aktif bile�enlerin temelini olu�tururlar. Ancak piyasadan kolayl�kla tedarik edilebilen bu do�al bile�iklerin baz� yan etkileri vard�r. Ayr�ca kullan�lan di�er ila�larla etkile�imleri olabilece�inden t�bbi denetim olmadan kullan�mlar� tehlikelidir. �ünkü do�al kaynaklardan elde edilen bir maddenin ila� olarak kullan�labilecek hale gelmesi i�in, bilimsel ara�t�rmalar ve klinik deneylerle desteklenen hem üretim a�amas�nda hem de ila� olarak ruhsatland�ktan sonra denetlenen uzun bir yol kat etmesi gerekir. Bu derlemede; ila�lar�n do�adan eczaneye ula�an tarihsel ve teknolojik �yküsü, do�adaki kaynaklar�, ruhsatl� ila� haline geli� a�amalar� ve do�al ürünler olarak pazarlanan ila� �ncüsü maddelerin denetimsiz kullan�m�n�n sak�ncalar� güncel literatür e�li�inde irdelenmi�tir.

Anahtar Kelimeler: �la�, do�al ila�, ilac�n sentezi, do�al maddelerin ila� olarak kullan�m�

The Mysterious Travel of Drugs from Nature to Pharmacy

G�lden D�N�Z¹, �ervan VEYSANO�LU², Simge �NAL², Buket ARA�², Neslihan D�zenli³, Emine M�ge KARAKAYALI²
¹Izmir Democracy University, Buca Seyfi Demirsoy Training and Research Hospital, Pathology Department
²Izmir Democracy University, Institute of Health Sciences, Medical Microbiology Department
³Izmir Democracy University Medical School, Medical Pharmacology Department

For thousands of years, people have used various substances found in nature to relieve symptoms and even cure diseases. Drugs are medicinal products obtained from natural sources such as plants, animals, and microorganisms or synthesized in the laboratory by taking these natural substances as examples. Even in some modern medical practices, drugs derived from natural components are still used. Many natural products, predominantly plants, contain chemical compounds with important pharmacological effects, and these compounds form the basis of active ingredients used in modern medicines. However, these natural compounds, which can be easily supplied from the market, may have some side effects. In addition, since there are several interactions with other drugs used, their use without medical supervision is dangerous. Because, for a substance obtained from natural sources to be used as a medical drug, it must go a long way, be supported by scientific research and clinical trials, and be controlled both during the production phase and after it is licensed as a medicine. In this review, the historical and technological story of drugs reaching the pharmacy from nature, their sources in nature, their stages of becoming licensed drugs, and the drawbacks of uncontrolled use of natural products are discussed in the light of current literature.

Keywords: Medical drugs, natural products, synthesis of drugs, use of natural substances as drugs

Sorumlu Yazar: G�lden D�N�Z, T�rkiye
Makale Dili: T�rk�e

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