Gebelikte �la� Maruziyetinin Prenatal ve Postnatal Sonu�lar�

�MERO�LU, �brahim; DEM�R, �mer; G�LBA�I, Hakan; U�AR, Elif; SEVER, Bar��; �ZER, Mehmet; EM�RAL�O�LU �AKIR, Z�beyde; YILDIRIM KARACA, Suna; G�LBA�I, Ceren; EK�N, Atalay

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Gebelikte �la� Maruziyetinin Prenatal ve Postnatal Sonu�lar� [Forbes J Med]

Forbes J Med. 2022; 3(1): 75-82 | DOI: 10.4274/forbes.galenos.2022.93723

Gebelikte �la� Maruziyetinin Prenatal ve Postnatal Sonu�lar�

�brahim �MERO�LU¹, �mer DEM�R², Hakan G�LBA�I³, Elif U�AR⁴, Bar�� SEVER¹, Mehmet �ZER¹, Z�beyde EM�RAL�O�LU �AKIR¹, Suna YILDIRIM KARACA⁵, Ceren G�LBA�I⁶, Atalay EK�N¹
¹Sa�l�k Bilimleri �niversitesi, �zmir Tepecik E�itim ve Ara�t�rma Hastanesi, Perinatoloji Klini�i, �zmir, T�rkiye
²Sa�l�k Bilimleri �niversitesi, �zmir Tepecik E�itim ve Ara�t�rma Hastanesi, Farmakoloji ve Ak�lc� �la� Poliklini�i, �zmir, T�rkiye
³Bak�r�ay �niversitesi, �i�li E�itim ve Ara�t�rma Hastanesi, Perinatoloji Klini�i, �zmir, T�rkiye
⁴�zel Esencan Hastanesi, Kad�n Hastal�klar� ve Do�um Klini�i, �stanbul, T�rkiye
⁵Sa�l�k Bilimleri �niversitesi, �zmir Tepecik E�itim ve Ara�t�rma Hastanesi, Kad�n Hastal�klar� ve Do�um Klini�i, �zmir, T�rkiye
⁶T�naztepe �niversitesi T�p Fak�ltesi, Kad�n Hastal�klar� ve Do�um Anabilim Dal�, �zmir, T�rkiye

Ama�: Hastanemize ba�vuran ve perinatoloji konseyimizde de�erlendirdi�imiz gebelerden ila� kullan�m �yk�s� olanlar�n demografik �zelliklerini ve maruz kal�nan ila�lar�n Yap�sal Tedavi Edici Kimyasallar S�n�flamas� (ATC) sistemine g�re da��l�mlar�n� belirlemektir.
Y�ntem: Bu ara�t�rma retrospektif kohort bir �al��ma olarak tasarlanm��t�r. Hastane veri taban�ndan elde edilen veriler, literat�r ��nda de�erlendirilmi�tir. Gebeli�inde ila� kullan�m� tespit edilen gebelerin s�kl�kla hangi ila�lar� kulland�klar� ATC sistemine g�re kategorize edildi. Ayn� zamanda gebelerin demografik verileri, e�itim durumlar�, gelir seviyeleri, alkol sigara kullan�mlar�, obstetrik sonu�lar� incelendi.
Bulgular: �al��mam�za �zmir Tepecik E�itim ve Ara�t�rma Hastanesi, Perinatoloji B�l�m� Konseyi�nde de�erlendirilen 99 gebe dahil edildi. Gebelerde ortalama ya� 31,70 [18-47, standart sapma (SS)=5,880], ortalama gravida 2,81 (1-8, SS=1,452), ortalama parite 1,4 (0-5, SS=0,988) ve ba�vuru s�ras�ndaki ortalama gebelik haftas� 11,27 (5-30, SS=4,692) olarak hesapland�. Ortalama ila� kullan�m s�resinin ortalama 66,56 g�n oldu�u tespit edildi. �al��mam�zda %29,33 oran�yla en s�k sinir sistemini ilgilendirilen ila�lar�n kullan�ld�� bunu %15,03 oran�yla sindirim sistemini ilgilendiren ila�lar�n takip etti�i g�zlendi. �laca maruz kalan 100 gebenin sadece 5�inde do�umsal anomali g�zlemlenmi�tir.
Sonu�: Gebelerin demografik verileri, maruz kald�klar� ila�lar�n da��l�mlar� literat�r ile benzer �ekildedir. Ancak daha �nceki �al��malardan farkl� olarak iste�e ba�l� k�retaj tercihi daha d��k orandad�r. Bununla birlikte do�umsal anomali g�r�lme durumu da beklenenden y�ksek de�ildir.

Anahtar Kelimeler: Gebelik, ila�, anomali, ATC s�n�flamas�, k�retaj

Prenatal and Postnatal Consequences of Drug Exposure in Pregnancy

�brahim �MERO�LU¹, �mer DEM�R², Hakan G�LBA�I³, Elif U�AR⁴, Bar�� SEVER¹, Mehmet �ZER¹, Z�beyde EM�RAL�O�LU �AKIR¹, Suna YILDIRIM KARACA⁵, Ceren G�LBA�I⁶, Atalay EK�N¹
¹Health Sciences University Tepecik Training And Research Hospital, Perinatology Clinic, �zmir
²Health Sciences University Tepecik Training And Research Hospital, Pharmacology And Rational Medicine Polyclinic, �zmir
³Bak�r�ay University �i�li Training And Research Hospital, Perinatology Clinic, �zmir
⁴Private Esencan Hospital,i̇stanbul
⁵Health Sciences University Tepecik Training And Research Hospital, Gynecology And Obstetrics Clinic, �zmir
⁶T�naztepe University Faculty Of Medicine, Gynecology And Obstetrics Clinic, �zmir

Objective: To determine the demographic characteristics of pregnant women that have a history of drug use and categorize the drugs according to the Anatomic Therapeutic Chemical Classification (ATC) system.
Methods: This study was designed as a retrospective cohort study. The data obtained from the hospital database were evaluated. The drugs used by pregnant women who were found to use drugs during pregnancy were categorized according to the ATC system. At the same time, demographic data, educational status, income levels, alcohol and cigarette use and obstetric results of the pregnant women were evaluated.
Results: Ninety-nine pregnant women evaluated in Tepecik Training and Research Hospital Perinatology Department Council were included. Mean age of pregnant women was 31.7 [18-47, standard deviation (SD)=5.880], mean gravida was 2.81 (1-8, SD=1.452), mean parity was 1.4 (0-5, SD=0.988) and mean gestational week at presentation was 11.27 (5-30, SD=4.692). It was determined that the mean duration of drug use was 66.56 days. It was found that drugs related to the nervous system were used most frequently with a rate of 29.33%, followed by drugs related to the digestive system with a rate of 15.03%. Congenital anomalies were observed in only 5 of 100 pregnant women exposed to the drug.
Conclusion: The demographic data of pregnant women and the distribution of the drugs they are exposed to are similar to the literature. However, unlike previous studies, the preference for optional curettage is lower and the incidence of congenital anomaly is not higher than expected.

Keywords: Pregnancy, drug, anomaly, ATC classification, curettage

Sorumlu Yazar: �brahim �MERO�LU, T�rkiye
Makale Dili: T�rk�e

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