Abstract
Objective: Polycystic ovary (PCO) syndrome (PCOS) is the most common endocrinopathy in women of reproductive age. The aim of this study was to reveal the place of omentin 1 in PCOS and whether it can be a diagnostic criterion.
Methods: Postmenarchal teenage girls aged 15-19 were included in the study. The total number of participants was 1.556. Sixty-three PCOS patients, 41 patients with PCO image on ultrasonography but no clinical or biochemical hyperandrogenism were included in the ultrasonographic PCO group. One hundred-fifty nine patients who were not diagnosed with PCOS were taken as the control group.
Results: A positive correlation was found between omentin 1 level and free androgen index, APO B/A1 ratio and total testosterone level (r=0.174, p=0.030). Omentin 1 level was at a normal level in cases with PCOS, and it was found to be highest in ultrasonographic PCOS and lowest in the normal group.
Conclusion: Omentin 1 is mostly associated with metabolic syndrome, especially insulin resistance in PCOS. In this context, omentin 1 finds its place more in the metabolic syndrome foot of PCOS. Omentin 1 was found to be high in the diagnosis of PCOS, rather than a low value, as claimed, because adolescents have not yet developed metabolic syndrome and, at least in our study group, the mean body mass index was 22 kg/m2. This situation reveals that this test has no diagnostic value in young adolescents who have not yet developed metabolic syndrome.
Keywords: Omentin 1, PCOS, metabolic syndrome, insulin resistance
